Abstract

Effect on the learning and memory activity of quercetin on colchicine induced amnesia in mice

The aim of present study is to investigate the therapeutic potential of quercetin in prevention of senile dementia of the Alzheimers type using intra-cerebroventricular administered Colchicine using Morris water maze model. Adult Swiss albino Wistar mice were treated with different dose of quercetin (Dose 5, 10, 20 and 40mg/kg) and the acquisition, retention and retrieval of spatial recognition memory was determined, by using Morris water maze models (interoceptive behavioral models). Prior administration of quercetin 40mg/kg with colchicine significantly decreased escape latency as compared to colchicine group. The use of quercetin warrants evaluation for the treatment of neurological disorder, which is associated with free radical generation and cognitive impairment such as Alzheimer’s disease.


Author(s): Aswin R. Deshmukh, Shital D. Pande, Anita S. Wagh, Swapnil G. Patiland Nishant Jain

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