Abstract

Effect of Carob(Ceratonia Siliqua L.) growing in Libya on cisplatin-induced nephrotoxicity in mice

Reactive oxygen species and free radicals are involved in the nephrotoxicity induced by the synthetic anticancer drug cisplatin. The nephrotoxicity effects of carob pods and leaves (100 and 200 m/kg, p.o.) were investigated using cisplatin (10mg/kg body weight, i.p.) to induce oxidative renal damage in mice. The results showed that cisplatin administration caused abnormal renal functions in all studied mice. Serum urea and creatinine concentration were significantly higher (p<0.5) in the cisplatin alone treated (control) group compared to the normal group. The concentrations of serum creatinine and urea in the carob pods (200 mg/kg body weight) treated group were reduced to 57.5% and 51.5%, respectively, with respect to the control group. Also, cisplatin induced decline of renal antioxidant enzymes such as Superoxide dismutase (SOD), Catalase (CAT), Glutathione peroxidase (GPX) activities, but the treatment of carob pods and leaves (100 and 200mg/kg, p.o) significantly attenuated the cisplatin- induced nephrotoxicity. Both pods and leaves of carob at 100 and 200 mg/kg increased the concentration of reduced lipid peroxidation .In addition, treatment with cisplatin increased the activity of cathepsin D, RNase II, DNase II and acid phosphatase. The treatment of carob pods and leaves (100 and 200 mg/kg, p.o.) improved the activity of lysosomal enzymes nearly to the normal group. In conclusion, carob leaves and pods may be effective to protect from oxidative renal damage and the leaves are the better nephroprotective agent than pods. The protection may be mediated partially by preventing the decline of renal antioxidant status.
Author(s): Maraia F. Elmhdwi

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