Dual Wavelength UV - Spectrophotometric Method for Simultaneous Estimation of Atorvastatin and Ezetimibe in bulk and their combined Tablet Dosage Form

A simple, accurate and precise dual wavelength spectrophotometric method was developed for simultaneous determination of Atorvastatin and Ezetimibe in combined pharmaceutical dosage form. The principle for dual wavelength method is “the absorbance difference between two points on the overlain spectra is directly proportional to the concentration of the component of interest”. The wavelengths selected for determination of Atorvastatin were 228.8 nm and 240.8 nm, whereas, the wavelengths selected for determination of Ezetmibe were 232 nm and 259.2nm. Methanol was taken as a solvent. Regression analysis of Beer’s plots showed good correlation in concentration range of 5-50 μg/ml for Atorvastatin and 5 - 30 μg/ml for Ezetimibe. Accuracy of method was found between 98.2 to 102.7%. The precision (intra‐day, inter‐day) of method was found within limits. The proposed method was successfully applied to determination of these drugs in commercial tablets.

Author(s): R Savithri, N Sai Sree Bindu, P Shiva Bhargavi, D H H Theja and P Ramalingam

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