Development of self micro emulsifying drug delivery system: Application to pimozide delivery

The objective of the present investigation was to formulate self micro emulsifying drug delivery system (SMEDDS) of Pimozide and was achieved by using Capmul MCM NF as oily phase, Cremophor RH 40 as Surfactant and PEG- 8000 as Co-Surfactant. Pimozide loaded SMEDDS were characterized with respect to Visual Assessment, Phase Separation, Emulsion Droplet Size, Pseudoternary Phase Diagram, HLB Determination, Assessment of Self- Emulsification Efficiency, Drug content and In- vitro dissolution study in comparison with ORAP® 2 mg tablet manufactured by TEVA Pharmaceuticals USA. Prepared Pimozide loaded SMEDDS showed excellent selfemulsification efficiency and released more than 90% of the drug in 45 minutes whereas ORAP® showed about 45% drug release. The mean globule size of optimized Pimozide SMEDDS was 29.39 nm.
Author(s): Packiaraj Jeyachandran Manohari, Janakiraman Kunchithapatham, Venkateswaran Chidambaram Seshadri and Chandrasekaran Muthusamy

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