Development and validation of UV spectrophotometric method for determination of Doxazosin Mesylate in tablet formulation

Determination of Doxazosin Mesylate in a fixed dosage form was carried out by UV Spectrophotometric method. The absorbance values were observed for different dilutions of drug at 245nm and which were used for the estimation of drug without mutual interference of excipients. The solvent used for the dilution was 0.01 N HCl. This method obeys Beer- Lambert’s law in the concentration range of 2-10 μg/ml. The results of analysis have been validated statistically and the recovery studies confirmed the accuracy of this proposed method.

Author(s): Shilpa P. Chaudhari, M. P. Ratmaparkhi, Neeraj R. Kotian, Mahesh M. Bhadgale and Vardhman C. Bafna

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