Development and validation of reverse phase HPLC method for determination of Simvastatin and Ezetimibe in tablet dosage form

In present study reverse phase HPLC method was developed for simultaneous estimation of simvastatin (SM) and ezetimibe (EZ) in tablet formulation. The separation was achieved by Eurosphere-100 C18 column and Methanol: Acetonitrile: Water (50:30:20v/v, pH 6.8 with phosphate buffer) as a mobile phase, at a flow rate of 1.0 mL/min. The UV detection was carried out at 240nm. The retention time of SM and EZ was found to be 5.077 min and 6.633 min respectively. The assay method was found to be linear in range of 5-25 mg/mL for SM and 5-30 mg/mL for EZ

Author(s): Sushil P Narkhede, Gali Vidyasagar, Anil G Jadhav, Sachin B Narkhede and Atul R Bendale

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