Development and validation of pH independent spectroscopic method for determination of Capecitabine

A simple, sensitive and pH independent spectrophotometric method has been developed for the determination of capecitabine in pharmaceutical formulations. The method is based on the measurement of absorbance at isosbestic point. Isosbestic point for capecitabine was observed at 256.3 nm and absorbances were measured at same wavelength. The method is found to be linear in the range of 10–20 µg/mL for Capecitabine with R2= 0.9987 (n=6). The proposed method is simple, rapid and gives accurate and precise results. Market formulations of capecitabine were analyzed with the proposed method. Results obtained are in good agreement with the labeled amount of capecitabine (99.7105± 0.2047, n=3) in tablet forms. The proposed method can be satisfactorily applied for estimation of capecitabine in pharmaceutical dosage form. The method can also be applied for estimation of capecitabine in aqueous medium irrespective of pH of solution

Author(s): Shailja H. Pateland Paresh U. Patel

Abstract | PDF

Share This Article
30+ Million Readerbase
Google Scholar citation report
Citations : 374

Der Pharmacia Sinica received 374 citations as per Google Scholar report

Abstracted/Indexed in
  • Google Scholar
  • Genamics JournalSeek
  • China National Knowledge Infrastructure (CNKI)
  • Directory of Research Journal Indexing (DRJI)
  • Proquest Summons
  • International Committee of Medical Journal Editors (ICMJE)
  • Serials Union Catalogue (SUNCAT)
  • Geneva Foundation for Medical Education and Research
  • Secret Search Engine Labs

View More »

Flyer image