Abstract

Development and validation of pH independent spectroscopic method for determination of Capecitabine

A simple, sensitive and pH independent spectrophotometric method has been developed for the determination of capecitabine in pharmaceutical formulations. The method is based on the measurement of absorbance at isosbestic point. Isosbestic point for capecitabine was observed at 256.3 nm and absorbances were measured at same wavelength. The method is found to be linear in the range of 10–20 µg/mL for Capecitabine with R2= 0.9987 (n=6). The proposed method is simple, rapid and gives accurate and precise results. Market formulations of capecitabine were analyzed with the proposed method. Results obtained are in good agreement with the labeled amount of capecitabine (99.7105± 0.2047, n=3) in tablet forms. The proposed method can be satisfactorily applied for estimation of capecitabine in pharmaceutical dosage form. The method can also be applied for estimation of capecitabine in aqueous medium irrespective of pH of solution


Author(s): Shailja H. Pateland Paresh U. Patel

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