Development and in-vitro evaluation of intra gastric cefadroxil monohydrate floating tablet

In the present investigation, an attempt has been made to increase therapeutic efficacy to reduce the frequency of administration and improve patient compliance by developing floating tablet of Cefadroxil monohydrate by using various grades of hydrophilic matrix forming polymer HPMC K100M and HPMC K15M, lactose, sodiumbicarbonate and citric acid use as gas generating agent. A 32 factorial design was applied systematically; the amount of HPMC K15M (X1) and amount of HPMC K100M(X2) were selected as independent variables. The time required for 50% drug release (t50%), percentage drug release at 12hr(Q12) percentage drug release at 6 hr (Q6 ) were selected as dependent variables. The tablets are prepared by direct compression method. The powder blend was evaluated for the bulk density, tapped density, angle of repose, compressibility index and Hausner ratio. The values indicate good flow and compression properties. The compressed tablets were evaluated in terms of their physical characteristics, in vitro release, buoyancy, buoyancy lag-time. All the observations are within the prescribed limits. . The in vitro data were fitted to different kinetic models.

Author(s): Umesh T. Jadhao, Vinod M. Thakare, Bharat W. Tekade, Kundan P. Chaudhari and Vijay R. Patil

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