Sulfonamides are an important class of drugs possessing antibacterial, anticarbonic anhydrase, diuretic, hypoglycemic and histone deacetylase (HDAC) inhibition activity. Inhibitors of HDAC have emerged as potential therapeutic agents against solid tumors and malignancies. Compounds from the sulfonamide class were designed by using the software Glide from Maestro 9.5 of Schrödinger, USA. Sulfonamides were synthesized from cinnamic acid as the starting material. These synthesized compounds were purified and characterized by Rf values in thin layer chromatography, melting points and IR spectroscopy. The structures were confirmed by 1H NMR spectroscopy. The compounds were evaluated for in vitro cytotoxicity against ovarian cancer cell line (OVCAR 3), using Sulphorhodamine B (SRB) assay. The hydroxamic acid derivatives of sulfonamides showed better activity compared to their triazole derivatives. One o-phenelynediamine derivative of sulfonamide also showed significant activity.