Design and evaluation of floating osmotic tablet of Nizatidine

Conventional drug delivery systems have little control over their drug release and almost no control over the effective concentration at the target site. The present work investigates the design of a novel floating osmotic tablet to prolong the gastric residence of a highly water-soluble drug. Nizatidine was chosen as a model drug. Floating Osmotic tablets of Nizatidine were prepared by direct compression method using polymers like HPMC, Carbopol in different proportions along with sodium bicarbonate as a gas generating agent. The prepared mass was passed through sieve and was evaluated for angle of repose, compressibility index and Hausner’s ratio and results obtained were satisfactory. Compressed formulations were further evaluated for weight variation, hardness, thickness, friability, buoyancy studies, drug content and in-vitro dissolution studies. All the formulations showed good results which were in compliance with pharmacopoeial standards. Among all formulations it was concluded that the F4 batch is optimized since it showed better drug release.

Author(s): Tanushree Sarkar

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