Comparative in vitro evaluation of commercially available rabeprazole tablets

The main aim of present investigation was to study some physico-chemical properties( thickness ,hardness, weight variation, friability and disintegration) and in vitro dissolution of most commercially available formulations of rebeprazole (encoded with RPZ-1, RPZ-2,RPZ-3) in Bangladesh and two multinational companies(encoded with RPZ-4 & RPZ-5).All the brands were within the pharmacopoeial limit when tested for thickness, weight variation, hardness, friability and disintegration.However, RPZ-3 showed the fastest disintegration. Moreover, the comparison of percentage drug release of these companies on the basis of dissolution study demonstrated that RPZ-2 (90 % drug release) complied best while RPZ-4 (74.58% drug release) does not comply with above specification.
Author(s): Most. Umme Bushra, Farjana Rahman, Md. Aftab Saleh Aziz and Mohammad Morsadul Islam

Abstract | PDF

Share This Article
30+ Million Readerbase
Google Scholar citation report
Citations : 374

Der Pharmacia Sinica received 374 citations as per Google Scholar report

Abstracted/Indexed in
  • Google Scholar
  • Genamics JournalSeek
  • China National Knowledge Infrastructure (CNKI)
  • Directory of Research Journal Indexing (DRJI)
  • Proquest Summons
  • International Committee of Medical Journal Editors (ICMJE)
  • Serials Union Catalogue (SUNCAT)
  • Geneva Foundation for Medical Education and Research
  • Secret Search Engine Labs

View More »

Flyer image