Abstract

Chronotherapeutic formulation of metformin hydrochloride

As a novel chronotherapeutic approach, in the present work a pulsatile drug delivery system for metformin hydrochloride was designed to control early morning hyperglycemia to synchronize the circadian rhythm of Diabetes Mellitus. The drug delivery system was prepared by using HPMC K100M as inner swellable and ethyl cellulose (18cps) as outer rupturable polymer. The core tablet was prepared by direct compression. The ethyl cellulose containing triethyl citrate as plasticizer was coated to core tablet by pan coating. The prepared film coated tablet was evaluated for in vitro drug dissolution study to get desirable immediate release of drug after lag time of 6 hours. Drug-excipients compatibility study by IR spectrophotometer showed that all the excipients were compatible with the drug. The stability study was carried out for the desired optimized formulation for a period of 3months and showed insignificant difference.
Author(s): Akila R. M. and Bharat Sharma

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