Chemopreventive activity of some spices against selected cell line

Herbs and spices have been traditionally used for prevention and cure of many diseases. Hence, the present study was aimed to investigate the effects of aqueous and alcoholic extract of four different spices (asafoetida, ginger, cinnamon and cardamom) extracts on human breast adenocarcinoma cell line (MCF) and HEP-G2 cancer cell lines through in-vitro growth inhibitory assay. Both aqueous and alcoholic extracts of spices (asafoetida, ginger, cinnamon and cardamom) showed significant activity as cytotoxicity agents for tumor cells. A significant decrease in MCF and HEP-G2 cell population by crude extract was observed. Among the spices assayed for their chemopreventive potential, asafoetida extract has shown the maximum inhibitory effect while cinnamon extracts showed minimum yet significant inhibitory action. Therefore, these spices might be used for natural healing of the tumor

Author(s): Neeraj Mishra and K. K. Behal

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