Biomathematical Model Study on the Association between Liver Fibrosis Disease and Anti-fibrotic Therapies Characteristics

Liver fibrosis was fully developed after CCl₄ induction for 7 weeks in eight animals. Clinical pathologic parameters, four indicators of hepatic fibrosis in monkey showed similarly changes in human. All animals had liver fibrosis after 1.5 months of CCl₄ induction, and liver fibrosis still existed after 9 months recovery periods, the fibrosis stages in most animals had no obvious regression without treatment. Biomathematical analysis of the liver fibrosis would aid to utilize the anti-fibrotic therapies and their derivatives for various biomedical applications.

Author(s): Bin Zhao*, Jinming Cao and Xia Jiang

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