Assay method development and validation of ibuprofen tablets by HPLC

A new simple, accurate, precise and reproducible a reverse phase high performance (RP-HPLC) method has been developed of ibuprofen in tablet dosage forms using C18 column (Hypersil BDS, 150 x 4.6 mm, 5 µm) in isocra tic mode. The mobile phase contains a combination of Acetate buffer (triethylamine & or tho phosphoric acid ) and acetonitrile in the ratio of 40:60% (v/v). The flow rate was 1.5 ml/min and detection wa velength was carried out at 220 nm. The retention times of ibuprofen was 3.2 min, respectively. The validation of method was carried out utilizing ICH guidelines. The described HPLC method was successfully employed for the analysis of pharmaceutical formulations containing Tablet dos age form.

Author(s): Sovan Pattanaik, Sangeeta Mukhi, Gurudutta Pattnaik and Jasmin Panda

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