Abstract

Anti-VEGF alter cognitive functions and the CA1-CA3 hippocampal activity in mice: The first reported Ã?¢ââ?? ¬Ã?â??ChemofogÃ?¢ââ?? ¬Ã?â?¢ with a targeted cancer therapy

Cancer sufferers handled with chemotherapy might also additionally display impaired cognition (Chemofog) long-time period after the remedy completion. Recently, centered treatment options were evolved and were additionally related to the advent of leukoencephalopathy and primary asthenia in most cancers sufferers. Our preceding paintings has diagnosed an instantaneous hyperlink among chemotherapy and impaired long-time period behavioral flexibility related to a reduced proliferation withinside the hippocampus and no cognitive dysfunctions after the most cancers remedy everolimus in mice. In this study, we evaluated the effect of the systemic management of an anti-VEGF antibody on cognitive function, hippocampal vascularization, cerebral metabolic pastime and hippocampal synaptic pastime in mice in addition to on proliferation of neural stem and endothelial cells in vitro. Antibodies towards the mouse VEGF


Author(s): Helene Castel

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