Abstract

Antitumor and cytotoxic effects of Phyllanthus polyphyllus on dalton's ascitic lymphoma and human cancer cell lines

The antitumor and cytotoxic activities of methanolic extract of Phyllanthus polyphyllus (MPP) were evaluated using mice and human cancer cell lines. The anticancer property of MPP was assessed against Dalton's ascitic lymphoma (DAL) tumor model by evaluating survival time, hematological parameters, lipid peroxidation (LPO), antioxidant enzymes like superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), glutathione peroxidase (GPx), solid tumor mass, and in vitro cytotoxicity (short-term). MPP (200 and 400 mg/kg) upon oral administration increased the survival time and reduced the solid tumor volume significantly in a dose-dependent manner. Packed cellular volume (PCV), protein, and hematological parameters were restored which were altered by tumor inoculation. MPP reduced the levels of LPO, GPx, GST, and increased the levels of SOD and CAT significantly. MTT assay was used to evaluate the cytotoxic activity using human cancer cell lines like cervical cancer cells (HeLa) and breast carcinoma cells (HBL-100). MPP showed IC50 values of 170 and 130μg/ml on HeLa and HBL- 100 cells respectively. MPP was found to possess significant antitumor and cytotoxic activity on DAL and human cancer cell lines.


Author(s): Swapna G

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