Abstract

Antinociceptive, antiinflammatory and antipyretic activities of Rumex hastatus D. don stem and roots

The antinociceptive, antiinflammatory and antipyretic activities of Rumex hastatus D. Don stem and roots were evaluated using several experimental models. The antinociceptive activity of the ethanol and aqueous extract of stem and root was determined by using acetic acid induced writhing method, tail flick model and formalin-induced pain model in mice, using standard drugs. The antiinflammatory activity was evaluated by using carrageenan induced rat paw oedema and cotton pellet induced granuloma method and the antipyretic activity was evaluated by using the technique of yeast-induced pyrexia in Wistar rats. The ethanol and aqueous extract of stem and root at the doses of 200 and 400 mg/kg showed a significant (P < 0.001) inhibition of acetic acid induced abdominal constrictions in mice. In the tail flick model, the ethanol extract (400mg/kg) showed a significant (P < 0.001) increase in the pain threshold to the heat stimulus. The ethanol extract (400 mg/kg) of both root and stem inhibited both phases of the formalin-induced pain with a more pronounced effect on the second than the first phase. In carrageenan induced rat paw oedema method, the ethanol extracts of both stem and root (400 mg/kg) exhibited significant anti-inflammatory activity. In cotton pellet induced granuloma method, the maximum percent inhibition was exhibited by ethanol extract (400 mg/kg) of the stem and root, which was 23.27% and 27.25% respectively. The ethanol extracts of both the parts at the doses of 400 mg/kg, produced a pronounced antipyretic effect in hyperthermic rats in a dose dependent manner when compared with untreated rats. Moreover the ethanol extracts were more active than the aqueous extracts of both the parts in terms of activities shown in this paper. The phytochemical analysis of the ethanolic extracts of both the parts showed the presence of anthraquinone glycosides, tannins, carbohydrates, saponins and steroids. The above results have furnished the pharmacological evidence that supports the folklore claim of the drug as an analgesic, antiinflammatory and antipyretic drug.


Author(s): Sumitra Singh, Rupinder Kaur and Surendra Kr. Sharma

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