Anti-inflammatory and ulcer prtotective activities of chloroform extract of Albizzia chinensis bark and its phytochemical studies

In endoscopic clinical research studies of patients who take non steroidal anti inflammatory drugs (NSAIDS) use, the incidence of new gastric ulcer in stomach. The NSIADS produced ulcer healing is not widely appreciated. The present study was undertaken to investigate anti inflammatory cum ulcer protective property of chloroform extract of Albizzia chinensis bark. The phytochemical studies were carried out chloroform extract of Albizzia chinensis bark. Carrageenan was used to induced rats paw oedema and diclofenac sodium (100 mg/kg, i.p route), which has been served for positive control. The etahanol induced ulcer was conducted in rats and omeprazole oral dose of 4mg/kg, which has been used for positive control. Ethanol administered 1hr later stomach was isolated from rat and histopathological studies were carried out chloroform extract of Albizzia chinensis bark. The phytochemical studies were indicated in the presence of carbohydrates, proteins, saponin glycosides, flavonoids, tannins, terpenoids, gums and mucilage. The results revealed that the chloroform extract of Albizzia chinensis bark 200 mg/kg and 400mg/kg dose levels have been showed significant decrease in the paw volume (P<0.001) when compared to control and positive control. The chloroform extract of Albizzia chinensis bark 200 and 400mg/kg dose levels were showed significantly reduced in the ulcer index (P<0.001) when compared to control and positive control. The histopathological studies have been indicated that the chloroform extract of Albizzia chinensis bark 200 and 400mg/kg were significantly increased in the ulcer protective effect when compared with control group.

Author(s): G. Nagaraja Perumal, R. Bhavani Shankar, S. Malini, V. Soumya, S. Janardhanan, V. Palanivel and K. L. Senthil Kumar

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