Abstract

Anti-inflammatory and analgesic effects of ethanolic leaf extract of Newbouldialaevis (P. Beauv.) Seemann Ex Bureau (Bignoniaceae)

Various parts of Newbouldialaevis (Bignoniaceae) including the leaves have been used to relieve stomach pains, pelvic pain, haemorrhoids, and rheumatic swellings in Ghanaian and West African folk medicine with little or no scientific evidence. This study was therefore aimed at evaluating the scientific basis for the traditional use of Newbouldialaevis leaves as an anti-inflammatory agent and analgesic using animal models. The chick inflammation model, tail immersion test, randallselitto test and formin test were used. One hour pre-treatment with the Newbouldialaevis extract (NLE) (30-300 mg kg-1; p.o.) significantly and dose dependently, inhibited foot edema in the chicks with maximal inhibition of 64.41±11.47%. In the tail immersion test, NLE (300 mg kg-1, p.o.) was able to significantly increase the withdrawal latency by 88.45±19.81%. Also, NLE (300 mg kg-1) reversed the inflammatoryinduced mechanical hyperalgesia with a maximum percentage effect of 37.60±7.26%. Treatment of mice with different doses of NLE (30–300 mg kg-1, p.o., 60 min before) produced a marked and dose-related inhibition of both phases of formalin-induced nociception with the highest dose given a maximal inhibition of 54.47±8.60% and 83.62±6.03% of the licking time in the first and second phases, respectively


Author(s): Eric Boakye-Gyasi, Wonder K. M. Abotsi and Eric Woode

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