Antihyperlipidemic Activity of the Methanolic extract from the Stems of Tinospora cordifolia on Sprague dawley rats

The work presented herein is about the cholesterol lowering properties of methanolic extracts of Tinospora cordifolia stems in hyperlipidemic Sprague dawley rats. Hyperlipidemia was induced in rats by once a day administration of cholesterol using olive oil as vehicle at 500 mg kg^-1 b.w. orally. The methanolic extracts of the stem of T. cordifolia at 200 mg kg^-1 b.w. and 400 mg kg^-1 b.w. were evaluated for their possible antihyperlipidemic activity by simultaneous administration along with cholesterol in olive oil orally for 30 days. There was a significant increase in total cholesterol, triglycerides, low density lipoprotein, high density lipoprotein and very low density lipoproteins in all the cholesterol fed groups, however the groups tested with methanolic extracts exhibited a significant reduction in their levels. The reduction was compared with standard atorvastatin and it was significant. The high density lipoproteins were relatively not affected and the reduction by the methanolic extract at 200 mg kg^-1 b.w. dose was insignificant, however at 400 mg kg^-1 dose there was a significant reduction in their levels. The plant needs a thorough phytochemical investigation to find the possible constituents responsible for the activity and to derive the exact mechanism of action.

Author(s): Thahera D. Parveen and Shaik Nyamathulla

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