Objective: Diabetes mellitus is a heterogeneous group of metabolic disorders characterized by persistent hyperglycaemia and becoming a serious threat to mankind health in all parts of the world. This study was designed to study the methanol leaf extract potential of Barringtonia Racemosa on Alloxan-induced diabetic.
Materials and Methods: The experimental rats were induced and made diabetic by single intra-peritoneal administration of Alloxan monohydrate at a dose rate of 160 mg/kg dissolved in 0.1 M freshly prepared citrate buffer at a base line pH 4.5. Extract of Barringtonia Racemosa (100, 200, 300, 400 and 500 mg/kg). Group 1 (normal rats) were administered distilled water, Group 2 (Diabetic untreated rats) were administrated distilled water, while Group 3 received the standard drug (Insulin) at 0.1 mg/kg and the rest of the groups 5-8 were administered the methanol extracts. Blood glucose was determined by glucose oxidase method of Trinder.
Results: The blood glucose data obtained using Alloxan hyperglycaemic rats, dose of the methanol extract indicated a significant difference in the level of blood glucose with increase in the extract concentration at different days of administration (p<0.05) with 053.4 ± 5.5 and 045.5 ± 5.8 higher than the control 066.6 ± 5.2 at 400 mg/kg and 500 mg/kg post treatment.
Conclusion: The blood glucose data obtained using Alloxan hyperglycaemic rats clearly shows that the methanol extract of Barringtonia Racemosa can produce significant and consistent hypoglycaemic effects.