ISSN : 0976 - 8688

Der Pharmacia Sinica

Abstract

Antidiabetic, antihyperlipidemic and antioxidant activities of methanolic extract of Alangium lamarkii in alloxan induced diabetic rats

Alangium lamarkii (family-Alangiaceae) have been used, traditionally, in the treatment of inflammations, blood disorders, burning sensation, spermatorrhoea, gleet, acute fever and lumbago. To investigate the antidiabetic, antihyperlipidemic and antioxidant activities of methanolic extract of Alangium lamarkii leaves in alloxan (ALX) induced diabetic rats. Diabetes was confirmed after 5 days of single intraperitoneal injection of ALX (150 mg/kg) in albino Wister rats. MEAL (200 and 400 mg/kg) orally administered daily for 15 days, blood was withdrawn for glucose determination on 0, 1, 10 and 15 days respectively. On the 15th day, overnight fasted rats were sacrificed and blood was collected for the determination of high density lipoproteins (HDL), low density lipoprotein (LDL), Triglycerides (TG). For in vitro antioxidant activity of MEAL, DPPH method was carried out. Methanolic extract of Alangium lamarkii leaves at doses of 200 and 400 mg/kg showed significant reduction is blood glucose, lipid profiles when compared to diabetic control group. We concluded that MEAL possesses antidiabetic, antihyperlipidemic and antioxidant activities.
Author(s): Bodhisattwa Chakraborty, Uttam Kumar Bhattacharyya, Sankhadip Bose, Rana Datta and Subhangkar Nandy

Abstract | PDF

Share This Article
Awards Nomination 17+ Million Readerbase
Google Scholar citation report
Citations : 4713

Der Pharmacia Sinica received 4713 citations as per Google Scholar report

Abstracted/Indexed in
  • Google Scholar
  • Genamics JournalSeek
  • China National Knowledge Infrastructure (CNKI)
  • Directory of Research Journal Indexing (DRJI)
  • Proquest Summons
  • MIAR
  • International Committee of Medical Journal Editors (ICMJE)
  • Serials Union Catalogue (SUNCAT)
  • Geneva Foundation for Medical Education and Research
  • Secret Search Engine Labs
  • CAS (Chemical Abstracting Services)
  • University of Barcelona

View More »