Antidiabetic activity of methanolic extract of root bark of Aegel marmelos in Alloxan-induced animal model

Aegel marmelos (L.) Corr., (Rutaceae; AG) is popularly known as bael tree, widely distributed throughout the Indian peninsula, Pakistan, Thailand, Bangladesh, Burma, and Sri Lanka. In the present study we have carried out the hypoglycemic activity of the standardized to total phenolic content of methanolic extract of AG (MAG) in experimental diabetic model. Inbreed adult male Charles-Foster (CF) albino rats were used in the experiment for hypoglycemic activity in oral glucose tolerance test (OGTT) and normoglycemic rats, and antidiabetic activity in alloxan induced rats. The results showed that the preliminary phytochemical screening revealed that MAG showed positive response to alkaloids, saponins and triterpenes, tannins, flavonoids, carbohydrates and sterols. Further, the MAG showed total phenolic content (198.8 mg/g). Moreover, the routine posttreatment for 21 days with the MAG showed potential hypoglycemic activity in OGTT and normoglycemic rats and antidiabetic activity in alloxan induced rat model in terms of significant hypolipidemic and antioxidant activity. In future, the isolation of specific compound from MAG and establishment of proper mechanism of action should to be carried out.

Author(s): Sweety Lanjhiyana, Debapriya Garabadu, Dheeraj Ahirwar, Papiya Bigoniya, Avtar Chand Rana, Kartik Chandra Patra, Sanjay Kumar Lanjhiyana and Murugan Karuppaih

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