Anticipating cardiac ischemic risk in cardiovascular patients through NMR metabolomics and Lipidomics

There is a clear need for new biomarkers capable of identifying patients at risk of plaque destabilization and rupture.Among various pathological features of atherosclerotic plaques that define their propensity to rupture, the content and composition of plaque lipids deserve special consideration. Altered lipid metabolism and dyslipidemia in the context of inflammation and oxidative stress are driving forces in the transition from stable to unstable plaques. We have recently performed comparative lipidomics profiling of carotid endarterectomy specimens from symptomatic versus asymptomatic patients and highlighted the existence of a characteristic lipid signature within unstable human plaques. This prompted us to further investigate molecular lipid profiles in the circulation.

Author(s): Domitilla Vanni

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