An efficient synthesis and in vitro antimicrobial activity of 1, 2, 4- Triazin-6-(5H)-one derivatives

A simple and efficient synthesis of 1, 2, 4- triazine derivatives is described by the condensation of 4-(2-susbtituted benzylidine)-2-phenyloxazol-5(4H)-one with 4-(4-Chlorophenyl)2- Hydrazinylthiazol in presence of sodium acetate in acetic acid. The newly synthesized compounds were evaluated for their antimicrobial activity. The structure of these compounds has been established on the basis of spectral data

Author(s): Baseer M.Shaikh, Santosh S. Chobe, Shankaraiah G.Konda, Namdev T. Khandare, Sanjay A. Chavan and Bhaskar S. Dawane

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