An Alkaloid from Indonesian’s Marine Sponges Xestospongia muta as Anti-dormant Mycobacterium Desulfovibrio desulfuricans

Isolation of secondary metabolite from Indonesian’s Marine Sponges Clathria sp., Xestospongia muta, and Endectyon delaubenfelsi against mycobacterium Desulfovibrio desulfuricans was completed on May 2018. Bioactive metabolites isolated based on bioassay-guided separation with several step of chromatography. The result of bioactivity showed that Xestospongia muta sponge has MIC₅₀ value=0,1 μg/mL, Clathria sp. has MIC₅₀ value=0.3 μg/mL and Endectyon delaubenfelsi has MIC₅₀ value=0.3 μg/mL. Interpretation of the FTIR spectrum from the Xestospongia muta sponge indicate the active-metabolite has an O-H functional group at 3435.56 cm^-1 with a fingerprint region of a C-O functional group at 1342.24 cm^-1. The active metabolite has a C-H methyl group at 2853.39 cm^-1 and C-H methylene at 2769.64 cm^-1 and a C≡N imine group at 2365.28 cm^-1 with fingerprint region of C-N imine functional group at 1637,27 cm^-1. The Results of cytotoxic show that MIC₅₀ value of Xestospongia muta has potential activity as the new model to the drug discovery against mycobacterium Desulfovibrio desulfuricans.

Author(s): Nanda Muhammad Razi, Syarifah Keumala, Guntur Febrian Illahi, Rauzatul Sakinah, Khairunnisa, Viqqi Kurnianda

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