Diabetes mellitus is a major health problem worldwide associated with neuropathy which has long been considered as a micro-vascular complication. In Chhattisgarh population, diabetic cases have not yet been systematically identified. Cases of related diseases like diabetic with hyperlipidemia and biochemical investigations into the role of glycosylated haemoglobin (Hb1Ac) on diabetes have revealed scanty attention. Hence the role of Hb1Ac in diabetic with neuropathy in Chhattisgarh was studied. The study was undertaken including both male and female subjects and the fasting blood sugar, post prandial blood sugar, HbA1c, urea, creatinine and uric acid were analyzed in the blood. The result indicated that the levels of fasting, postprandial blood sugar and Hb1Ac were elevated significantly (P<0.05) in diabetes associated neuropathy compared to control and neuropathy, however, there was no change compared to diabetes. Further, urea level increased significantly (P<0.05) in diabetes, neuropathy and diabetes associated neuropathy compared to control, however there was no difference between diabetes, neuropathy and diabetes associated neuropathy. The creatinine level increased significantly (P<0.05) in both neuropathy and diabetes associated neuropathy compared to both control and diabetes. The uric acid level increased in neuropathy and diabetes associated neuropathy compared to control. However, neuropathy subjects showed significant increase in uric acid level and diabetes associated neuropathy did not show any change compared to diabetes. Moreover, diabetes associated neuropathy showed decresed uric acid level compared to neuropathy only. In conclusion, Hb1Ac would be a good tool for the monitor of the pathobiogenesis and treatment of diabetes associated neuropathy.