A new route to the preparation of spiroheterocyclic compounds

Owing to the extensive pharmacological importance, heterocyclic compounds are often synthesized with varying substituents. The main objective of such synthesis is to study the activity related aspects of pharmacophore groups of the heterocyclic compounds and to enhance the yield of the compounds if found significantly active. Since spiro hetrocycles are expected to be pharmacologically active, compounds viz., N-[1-acetyl-7,9-diphenyl-4-oxa-8-thia-1,2-diazaspiro(4.5)dec-2-en-3-yl]acetamide and N-[1-acetyl-7,9-diphenyl-4,8-dithia-1,2-diazaspiro(4.5)dec-2-en-yl]acetamide have been synthesized and characterized by C,H,N anaylsis, IR, 1H-NMR and 13C-NMR data

Author(s): M. I. Fazal Mohamed1 , M. Seeni Mubarak2, Mukhtar Ahmad Dar3, M. Natarajan4

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