A Concise Review Based On Analytical Method Development and Validation Of Pregabalin

In Pregabalin is an antiepileptic drug, also called an anticonvulsant. It is the first drug which receives approved labeling from FDA for the treatment of painful diabetic neuropathy postherpetic neuralgia. It works by slowing down the impulses in the brain which causes seizures. The present critical revive assesses the completion of various article which have already been published describing analytical method and method validation for the same.The comprehensive review account, the disclosed analytical method are outlined for the establishment of pregabalin in its pharmaceutical preparations, bulk drug & biological matrices. Now days most frequently used methods such as spectrometric and liquid chromatographic method were summarized in this review. Spectrometric methods for pregabalin alone and in combination are given in Table no.1 & Table no.2.which includes parameters like λmax, solvent, matrix etc. The HPLC method for pregabalin both sole & in combination are given in Table no. 3 & 4.Includes parameters like matrix, stationary phase, mobile phase composition, detection wavelength etc. HPTLC method reported in Table no. 5 includes parameter like matrix, stationary phase, mobile phase, RF etc. The table no. 6 & 7 includes the LC-MS/MS method for pregablin for alone & in combination which involve the parameters like stationary phase, mobile phase composition, internal factor, flow rate etc.

Author(s): Pritam S. Jain* , Urmila R. Salunke, Santosh B. Bodkhe

Abstract | Full-Text | PDF

Share This Article