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Synthesis, Characterization, Antibacterial, Antifungal Screening and Cytotoxic Activity Of Schiff Base Nickel(II) Complexes with Substituted Benzylidine Aminobenzoic Acid

The synthesis, characterisation and antimicrobial study of Ni(II) complexes from Schiff base ligands L1 and L2 are recorded in this study. The ligand L1, 2-((2-hydroxy-3-methoxybenzylidene)amino) benzoic acid obtained by the condensation of o-vanillin and 2-aminobenzoic acid and the ligand L2, 2-((2-hydroxybenzylidene) amino)benzoic acid is obtained by the condensation of salicylaldehyde and 2-aminobenzoic acid. The ligands and the complexes were characterised by molar conductance, vibrational, electronic, 1H-NMR spectrum and redox sudies. The molar conductance of these complexes convey the non-ionic character of the complexes. The spectral data show the composition of the metal complexes to be ML (L is the Schiff bases L1 and L2).Antibacterial as well as antifungal activities of these complexes of Ni(II) with the Schiff bases have been performed by disc diffusion method.The evaluated highly biologically active [Ni(L2-2H)(H2O)3].H2O complex shows excellent cytotoxicity towards (MG-63) cancer cell line.The results of the characterisation and biological activities are elaborately discussed in this paper.

Author(s): Govindaraj V, Ramanathan S and Murgasen S

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  • Chemical Abstracts Service (CAS)
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  • China National Knowledge Infrastructure (CNKI)
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  • International Committee of Medical Journal Editors (ICMJE)
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