Objective: Diabetes mellitus is a heterogeneous group of metabolic disorders characterized by persistent hyperglycaemia and becoming a serious threat to mankind health in all parts of the world. This study was designed to study the methanol leaf extract potential of Barringtonia Racemosa on Alloxan-induced diabetic.
Materials and Methods: The experimental rats were induced and made diabetic by single intra-peritoneal administration of Alloxan monohydrate at a dose rate of 160 mg/kg dissolved in 0.1 M freshly prepared citrate buffer at a base line pH 4.5. Extract of Barringtonia Racemosa (100, 200, 300, 400 and 500 mg/kg). Group 1 (normal rats) were administered distilled water, Group 2 (Diabetic untreated rats) were administrated distilled water, while Group 3 received the standard drug (Insulin) at 0.1 mg/kg and the rest of the groups 5-8 were administered the methanol extracts. Blood glucose was determined by glucose oxidase method of Trinder.
Results: The blood glucose data obtained using Alloxan hyperglycaemic rats, dose of the methanol extract indicated a significant difference in the level of blood glucose with increase in the extract concentration at different days of administration (p<0.05) with 053.4 ± 5.5 and 045.5 ± 5.8 higher than the control 066.6 ± 5.2 at 400 mg/kg and 500 mg/kg post treatment.
Conclusion: The blood glucose data obtained using Alloxan hyperglycaemic rats clearly shows that the methanol extract of Barringtonia Racemosa can produce significant and consistent hypoglycaemic effects.
All Published work is licensed under a Creative Commons Attribution 4.0 International License
Copyright © 2019 All rights reserved. iMedPub LTD Last revised : September 16, 2019