Antidiabetic, antihyperlipidemic and antioxidant activities of methanolic extract of Alangium lamarkii in alloxan induced diabetic rats

Alangium lamarkii (family-Alangiaceae) have been used, traditionally, in the treatment of inflammations, blood disorders, burning sensation, spermatorrhoea, gleet, acute fever and lumbago. To investigate the antidiabetic, antihyperlipidemic and antioxidant activities of methanolic extract of Alangium lamarkii leaves in alloxan (ALX) induced diabetic rats. Diabetes was confirmed after 5 days of single intraperitoneal injection of ALX (150 mg/kg) in albino Wister rats. MEAL (200 and 400 mg/kg) orally administered daily for 15 days, blood was withdrawn for glucose determination on 0, 1, 10 and 15 days respectively. On the 15th day, overnight fasted rats were sacrificed and blood was collected for the determination of high density lipoproteins (HDL), low density lipoprotein (LDL), Triglycerides (TG). For in vitro antioxidant activity of MEAL, DPPH method was carried out. Methanolic extract of Alangium lamarkii leaves at doses of 200 and 400 mg/kg showed significant reduction is blood glucose, lipid profiles when compared to diabetic control group. We concluded that MEAL possesses antidiabetic, antihyperlipidemic and antioxidant activities.
Author(s): Bodhisattwa Chakraborty, Uttam Kumar Bhattacharyya, Sankhadip Bose, Rana Datta and Subhangkar Nandy

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