Animal Venom Derived Toxins are Novel Analgesics for Treatment of Arthritis

Present review article explains use of animal venom derived toxins as analgesics of the treatment of chronic pain and inflammation occurs in arthritis. It is a progressive degenerative joint disease that put major impact on joint function and quality of life. Patients face prolonged inappropriate inflammatory responses and bone erosion. Longer persistent chronic pain is a complex and debilitating condition associated with a large personal, mental, physical and socioeconomic burden. However, for mitigation of inflammation and sever pain in joints synthetic analgesics are used to provide quick relief from pain but they impose many long term side effects. Venom toxins showed high affinity to voltage gated channels, and pain receptors. These are strong inhibitors of ion channels which enable them as potential therapeutic agents for the treatment of pain. Present article emphasizes development of a new class of analgesic agents in form of venom derived toxins for the treatment of arthritis.

Author(s):  Ravi Kant Upadhay

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