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Xenobiotic Metabolism Innovations

The metabolism of pharmaceutical drugs is a crucial aspect of pharmacology and medicine. For instance, the speed of metabolism determines the duration and intensity of a drug's pharmacologic action. Drug metabolism also affects multidrug resistance in infectious diseases and in chemotherapy for cancer, and therefore the actions of some drugs as substrates or inhibitors of enzymes involved in xenobiotic metabolism are a standard reason for hazardous drug interactions. These pathways also are important in ecology, with the xenobiotic metabolism of microorganisms determining whether a pollutant are going to be weakened during bioremediation, or continue the environment. The enzymes of xenobiotic metabolism, particularly the glutathione S-transferases also are important in agriculture, since they'll produce resistance to pesticides and herbicides

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