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Structural Glycobiology

The Research Group “Structural Glycobiology” has a strong focus on protein-ligand interactions using biophysical and computational techniques as well as cell-based methods. In particular, we are interested in glycan-binding proteins important to immunity, developing small molecular inhibitors as well as studying the recognition of their natural carbohydrate ligands. These findings are combined with functional studies of glycan-binding proteins in their native environment to foster our understanding of glycobiology in a structural context. In particular we have accumulated expertise in the study of the enzyme acetylcholinesterase and of the extracellular ligand-binding domain of the nicotinic receptor to acetylcholine whose malfunctioning has been correlated with neurodegenerative diseases, and to cell adhesion molecules structurally related to the cholinesterases or to other families of proteins and associated with developmental neuronal deficiencies.

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