Endocrinology and Metabolism: Open Access

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Primary Aldosteronism

Primary aldosteronism (PA), also known as primary hyperaldosteronism or Cl's syndrome, refers to excessive production of the hormone aldosterone from adrenal glands, leading to low renin levels. This discomfort is caused by hyperplasia or tumor. Many suffer from fatigue, high potassium deficiency and high blood pressure which can cause poor eyesight, confusion or headaches. Symptoms may include: muscle weakness and weakness, muscle cramps, lower back and kidney pain, tremors, tingling sensations, impatience and excessive urination. Complications include heart disease such as stroke, myocardial infarction, kidney failure and cardiovascular rigidity. Primary hyperaldosteronism has many causes. About 33% of cases are due to adrenal adenoma producing aldosterone, and 66% of cases are due to an increase in both adrenal glands. Other less common causes include adrenal cancer and inherited disability called Famal hyperaldosteronism.

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