Metformin, promoted under the exchange name Glucophage among others, is the primary line drug for the treatment of type 2 diabetes, especially in individuals who are overweight.[8] It is additionally utilized in the treatment of polycystic ovary syndrome.[6] It isn't related with weight gain.[9] It is taken by mouth.[6]Metformin is commonly well tolerated.[10] Common unfriendly impacts incorporate looseness of the bowels, sickness, and stomach pain.[6] It has an okay of causing low blood sugar.[6] High blood lactic corrosive level is a worry if the prescription is utilized in excessively enormous portions or endorsed in people with extreme kidney problems.[11][12] It isn't suggested in those with critical liver disease.[6] While no unmistakable mischief originates from use during pregnancy, insulin is commonly favored for gestational diabetes.[6][13] Metformin is a biguanide antihyperglycemic agent.[6] It works by diminishing glucose creation by the liver, by expanding the insulin affectability of body tissues,[6] and by applying an anorexiant impact, along these lines lessening caloric admission. Metformin was found in 1922.[15] French doctor Jean Sterne started concentrate in people in the 1950s.[15] It was presented as a drug in France in 1957 and the United States in 1995.[6][16] It is on the World Health Organization's List of Essential Medicines, the most secure and best prescriptions required in a wellbeing system.[17] Metformin is the most broadly utilized drug for diabetes taken by mouth.[15] It is accessible as a conventional drug