Diabetes Care and Treatment

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It contains quite 5788 small molecule compounds, with known biological activities causing biological reaction in cells, tissue even whole body, including Clinical compound library (L3400), Preclinical compound library (L3410), and Approved drug library (L1000). All compounds have clear targets and detailed information description, which is that the key point to drug research and development like drug repurposing, small molecule inducing somatic cell differentiation, and target identification in mechanism interrogation.

 

Many scientists have identified small molecules which will regulate cell fate and performance , and somatic cell differentiation by screening annotated bioactive compound library with confirmed activity and known targets. Recent advances in iPSC technology have made reprogramming of somatic cells towards pluripotency possible and simpler. Using both phenotypic screening and hypothesis-driven approaches, a growing number of compounds are identified which will functionally replace reprogramming transcription factors, enhance efficiency of iPSC generation and accelerate the reprogramming process by single use or a mixture of several molecules successfully in cardiomyocyte differentiation and proliferation, neural progenitor cells, etc.

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