Journal of Cell and Developmental Biology

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Cell Aging Journals

Cell ageing is defined as the reduction in the tolerance to stress and other cellular wear & tear, wich causes a gradual loss of cellular functionalities and resulting eventually in apoptosis. Till now, the mechanisms of ageing, whether replicative or chronological, are not defined elaborately. Research using various genetic model organisms led to the identification of about twenty genes that can prolong the lifespan of an organism. Moreover, studies using Caenorhabditis elegans, mouse, and yeast models revealed the occurrence of common mechanisms that control ageing in these organisms. For example, studies in S. cerevisiae resulted in the identification of two cellular pathways which were involved in the control of chronological ageing. One of them is the RAS/cAMP/PKA pathway. The other one, is based on the revelation of SCH9 gene. These pathways are involved in the regulation of the cell’s defence response against free radicals, and other reactive oxygen molecules that gradually accumulate in the cell and damage macromolecules such as DNA, RNA and proteins.

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Citations : 79

Journal of Cell and Developmental Biology received 79 citations as per Google Scholar report

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