Chemical Informatics

Amplification Refractory Mutation System

The amplification refractory mutation system (ARMS) is an amplification strategy during which a polymerase chain reaction (PCR) primer is meant in such how that it's ready to discriminate among templates that differ by one nucleotide residue ARMS has also been termed allele-specific PCR (3) or PCR amplification of specific alleles Thus, an ARMS primer are often designed to amplify a selected member of a multi-allelic system while remaining refractory to amplification of another allele which will differ by as little as one base from the previous . The most advantage of ARMS is that the amplification step and therefore the diagnostic steps are combined, therein the presence of an amplified product indicates the presence of a specific allele and the other way around. For routine diagnosis, this characteristic of ARMS means it's a really time-efficient method. However, this mix of the amplification and diagnostic steps has resulted during a system which will not be as robust as a number of the opposite methods during which these two important steps are separated, e.g., PCR followed by restriction endonuclease analysis,

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Amplification Refractory Mutation System

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