Aldosterone Journals

Aldosterone may be a hormone produced within the adrenal . This steroid molecule, derived from cholesterol, promotes retention of sodium and water and lowers the amount of potassium within the blood through many mechanisms, including action on the mineralocorticoid receptors within the kidneys. It plays a central role within the regulation of vital sign . Aldosterone stimulates reabsorption of sodium, sustaining blood volume and pressure within the face of salt deprivation or ECF depletion. The steroid also stimulates excretion of potassium, protecting ECF from excessive levels of that ion. These two actions are relatively rapid adaptive when appropriately initiated and terminated, but maladaptive when prolonged or excessive, causing hypertension and electrolyte imbalance. Aldosterone and other mineralocorticoids are direct effects on cells within the heart, kidneys, and vessels, resulting in hypertrophy, fibrosis, and dysfunction contributing to degenerative cardiovascular diseases. The maladaptive actions of aldosterone are exacerbated by common salt , angiotensin, endothelin, and certain growth factors.

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