Journal of Organic & Inorganic Chemistry

The potential of Garcinia atroviridis as therapeutic agents

Euroscicon Conference on Physical Chemistry and Analytical Separation Techniques
October 08-09, 2018 Amsterdam, Netherlands

Wen Nee Tan, Melati Khairuddean and Nik Nur Syazni Nik Mohamed Kamal

Universiti Sains Malaysia (USM), Malaysia

Posters & Accepted Abstracts: J Org Inorg Chem

DOI: 10.21767/2472-1123-C6-018

Abstract

Garcinia atroviridis locally known as asam gelugor in Malaysia can be found wild in the forest of peninsular Malaysia. Traditionally, G. atroviridis has been used as a postpartum medication agent to treat earache, throat irritation, cough, dandruff and stomach ache. The essential oils from different plant parts of G. atroviridis, viz., fruit, stem bark and leaf were obtained by hydrodistillation. Analysis by gas chromatography and gas chromatography-mass spectrometry revealed the presence of sesquiterpenoids in the fruit and leaf oils while fatty acids was predominated in the stem bark oil. In vitro MTT assay on human breast cancer cells showed that the leaf oil induced anti-proliferative effects in a dose- and time-dependent manner. In a combination treatment with tamoxifen, the leaf oil induced more cell death than the treatment using the drug alone. Thus, there is a need to further explore G. atroviridis essential oils as this may lead to the discovery of potential chemotherapeutic agents.

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