Journal of Organic & Inorganic Chemistry

Sulfated polyborate catalysed – solvent free and recyclable catalyst for efficient synthesis of betti base

EuroSciCon Conference on Chemistry 2018
February 19-20, 2018 Paris, France

Manisha S Patil, Chetan Khatri and Ganesh U Chaturbhuj

Institute of Chemical Technology, Mumbai, India

Posters & Accepted Abstracts: J Org Inorg Chem

DOI: 10.21767/2472-1123-C1-003

Abstract

In 1900, Betti was the first to prepare 1-(a-aminobenzyl)-2-naphthol by simple condensation of 2-naphthol with benzaldehyde and ammonia. Aminoalkyl naphthols (Betti bases) and amidoalkyl naphthols with 1,3-amino-oxygenated Functional group are considered as a class of biologically natural active products and potent drugs, which include many nucleosides, antibiotics, and human immunodeficiency virus protease inhibitors, such as lopinavir and ritonavir. Several Lewis and Br�?¸nsted acids such as SnCl45H2O, polymersupported sulfonic acid, ionic liquids, nano-sulfated zirconia, [HMIM]C(CN)3, ZrO(OTf)2, Bi(NO3)3.5H2O have been applied to catalyze this transformation. However these catalytic systems suffer from one of the following limitation such as the use of expensive and toxic reagents/catalysts, limited availability of reagent, hygroscopicity as well as instability of the reagents, use of strong protic media, harsh reaction condition, long reaction time, low yields, tedious work up procedure. In this work efficient, mild and eco-friendly procedure of 1-aminoalkyl-2-phenol/betti base from one pot three component condensations of Aldehyde, Phenol and Morpholine in presence of sulfated polyborate catalyst, under solvent-free condition at 100�?°C (Scheme 1). The catalyst has been prepared and used as a Bronsted as well as Lewis acid catalyst for the reaction. The catalyst was prepared by dehydration of boric acid followed by sulfonation and characterized by different analytical techniques such as potentiometric analysis, FTIR, XRD, SEM-EDAX. The major advantages of the present method are short reaction time, high yields, Aqueous workup procedure, Low cost, stable, reusable catalyst and solvent-free reaction conditions are the key features of the present protocol.

Biography

Manisha S Patil has completed her MPharm from North Maharashtra University and PhD Studies from Institute of Chemical Technology. She has recently published 3 papers in reputed journals in short time.
Email:msp214@gmail.com