Henrich H. Paradies and Hendrick Reichelt
Jacobs-University, Germany Salford University, United Kingdom
ScientificTracks Abstracts: Struct Chem Crystallogr Commun
The role of halogens in racemic 4-hal-4-butyl (n-octyl)-1phenyl derivatives (hal: F, Cl, Br), of the cyclic pyrazoline(1,3)-diones in the solid state and in solution was determined . Noncovalent interactions are observed for the F, Cl and Br derivatives between the halogen atom and the hydrogen atom of the nitrogen of the pyrazolidine ring, water hydrogens that interact either with the halogen atoms or with the carbonyl oxygen atoms very different from the none-halogenated pyrazoline-diones [2-5]. The 3d and 2d structures are stabilized by - and - interactions, intermolecular distances, and apolar forces between adjacently stacked phenyl rings. However, the R-or S-enantiomers or their water-stable complexes with Znmeglumine did not racemizes in aqueous dispersions [1,3]. Small-angle-, wide-angle x-ray scattering experiments, and molecular simulation reveal similar solution structure factors, S(Q), in the solid state and in solution [6,7]. The planes and their periodicities of the crystalline phases are preserved in the aqueous solution phase. There is also hydrogen bonding formed in the racemic and the R-enantiomeric n-octyl-1phenyl-1-Cl-pyrazoline-(1,3)-dione between the hydrogens of the water molecules and the halogens of the pyrazolidine ring: Cl forms a hydrogen bond to the water hydroxy group of a neighbouring molecule, which is hydrogen bonded to the chlorine of another molecule forming a 1-dimensional hydrogen-chloride bond network differently from hydrated cationic lipids or their polymorphs [8,9]. The n-octyl pyrazolidine approximant forms micelles in aqueous dispersions that selfassemble into quasicrystalline structures. The small-angle X-ray scattering experiments and the selected area electron diffraction pattern of thin films suggest that the micelle FCC phase transforms into a colloidal quasicrystalline phase with 12-fold symmetry that proceed through rearrangements of the micelles in the (111) layers of the FCC phase. The differences of the halogenated cyclic and non-cyclic pyrazoline diones are related to biochemical changes in anti-inflammatory activities. The n-octyl compound reveal antimicrobial and antiviral (influenza) activities but no anti-inflammatory or analgesic activities.
Recent Publications 1. Reichelt H., Paradies H.H. (2018) Structures and anti- inflammatory properties of 4-halogenatedmofeburazones. J. Mol. Structure, 1154: 204-218. 2. Paradies H.H., Ziedrich H.K., Flämig, H. H. (1990) Structural studies on mofebutazone derivatives and their in-vitro activities. J. Med. Chem. 25: 143-156. 3. Paradies H.H, (1987) Structure of phenylbutazone and mofebutazone in the crystalline state and in solution. J. Pharm.Sci.76:820-929. 4. Paradies H.H., Ziedrich H.K., Flämig H. H. Gan T. G. (1987) Keto-enol tautomer of 1-phenyl-4n-butylpyrazolidin- (1,5) - dione. Acta Technol. 33:180-188. 5. Paradies H. H., Schulte K.E. (1988) The Role of 2-(S)n-Butyl- (1-Phenyl-Hydrazino-Carbonly)-Hexanoic Acid in the Anti- Inflammatory Process, Ann. New York Acad. Sci. 529: 221- 227. 6. Reichelt H., Faunce C. A., Paradies H. H. (2015) Structures of the 2-nitrophenol alkali complexes in solution and the solid state, J. Chem. Phys. 143: 044307-044324. 7. Paradies H. H., Reichelt, H. (2016) Influence of the anions on the N-cationic benzethonium salts in the solid state and solution: Chloride, bromide hydroxide and citrate hydrates, AIPAdvances6:065322-065346.
8. Paradies H. H., Habben F. (1990) The crystal and molecular structure of hexadecylpyridinium chloride, Acta Cryst.: C 49, 744-748. 9. Alonso B., Massiot D., Florian P., Paradies H. H., Gaveau P., Mineva T. (2009) 14N and 81Br quadrupolar nuclei as sensitive NMR probes of n-alkyl trimethylammonium bromide crystal structures. An experimental and theoretical study, J. Phys. Chem. B.113: 11906-11920.
Prof. Henrich H. Paradies, FRSC & CC, MD, Ph.D., Ph.D., D.Sc. (h.c.) studied bioinspired, smart and multi-scale materials with defined wettabilities of cationic lipids as components in antiviral, antibacterial, and anti-inflammatory ingredients, the inhibition of viral activities on the level of monomer or aggregated sizes (cyclic peptides), adherence for brushy surfaces by clinging to flaws and function of the organization on their specific head groups e.g. ammonium vs. phosphonium groups, Zn-cationic lipid-alendronate complexes or cyclic peptides with antimicrobial activities. The uptake of these materials is dependent on free diffusion, micelle endocytosis, distribution through the cytoplasms and disassembles into monomer to unfold full biological activities. A unique role plays the lipid A-phosphates and their approximants as antagonist for chronic inflammation, food poisoning, allergens and resistance against antibiotics. The mechanics and physics of these supramolecular assemblies were analyzed in terms of bond-orientational order, mean field phase diagram and disproportionate crystals or quasicrystals. (orcid. org/0001-0003-9409-3471).