Soliman Mohammadi-Samani, Shirin Zojaji and Elaheh Entezar-Almahdi
Shiraz University of Medical Sciences, Iran International Branch of Shiraz University of Medical Sciences, Iran
Posters & Accepted Abstracts: Am J Ethnomed
During the recent years, there has been rising attention to the development of topical delivery systems to facilitate drug permeation through the skin. The drugs commonly used are those with debatable oral administration. Although piroxicam is a valuable anti-inflammatory, antipyretic and analgesic drug, long term oral administration is limited due to the various GI side effects. The main aim of this study was to prepare and assess a topical formulation of piroxicam based on Solid Lipid Nanoparticles (SLNs), to improve its percutaneous permeation rate. Topical nano-lipidic gel of piroxicam was formulated and its pharmaceutical characteristics were evaluated. Piroxicam loaded SLNs were formulated by solvent emulsification evaporation method. The SLNs were composed of stearic acid and cholesterol as lipid phase, Brij35 and Brij72 as a stabilizer and acetone was used to dissolve the lipidic ingredients of the formulation. Particle size assessment, drug loading determination, entrapment efficiency assessment, and in vitro release study and skin permeation of the piroxicam was determined to characterize the SLNs and then these nanoparticles were formulated in gel as topical delivery system to assess percutaneous permeation of piroxicam. The SLNs were prepared in different size ranges from 100-300 nm and drug release behavior from two different nano-sized SLN suspensions was evaluated. Piroxicam nano-lipidic gel showed increased skin permeation of the drug over commercial piroxicam gel formulation and also mean particle size of formulated SLNs had significant effect on permeation rates.
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