Journal of Organic & Inorganic Chemistry

Organic and organometallic derivatives of tocopherol mimetics as promising antioxidants with dual functionality

6^th Edition of International Conference and Exhibition on Organic Chemistry
August 16-17, 2018 Dublin, Ireland

Elena R Milaeva

Lomonosov Moscow State University, Russia

ScientificTracks Abstracts: J Org Inorg Chem

DOI: 10.21767/2472-1123-C4-011

Abstract

The presentation will focus on a novel approach to construction of physiologically active organic and organometallic compounds based on computer-aided design, new synthetic approaches and extensive biological screenings. This study is focused on the design of hybrid compounds possessing 2,6-dialkylphenol group with dual modes of action – prooxidative activity and antioxidative activity. The presence of metal atom allows extensive modification including coordination to the targeted specific groups to control and tune toxicity-activity profiles. The synthesis and biological activity will be discussed. The anti/prooxidant activity has been studied in vitro, ex vivo, in vivo experiments.

Biography

Elena R Milaeva pursued PhD at the A N Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences in 1980. She is currently a Professor of organic chemistry, head of the department of medicinal chemistry & fine organic synthesis at Lomonosov Moscow State University respectively. Her research interests include: organic chemistry, medicinal chemistry, organometallic chemistry.

E-mail: milaeva@med.chem.msu.ru helenamilaeva@mail.ru