Journal of Heart and Cardiovascular Research

New method for determining blood pressure in unanaesthesized rats using noninvasive CONTEC 08A device with small cuff: A path to antihypertensive drug development in developing countries

22^nd International Conference on New Horizons in Cardiology & Cardiologists Education
March 07-08, 2019 Berlin, Germany

Abiola Muhammad Adeosun, Ighodaro O M and Akinloye O A

Lead City University, Nigeria Federal University of Agriculture, Nigeria

Posters & Accepted Abstracts: J Heart Cardiovasc Res

DOI: 10.21767/2576-1455-C1-003

Abstract

Invasive method of determining blood pressure has been the commonly used method in animal model of hypertension study. Currently used noninvasive blood pressure monitoring devices are very costly and unaffordable by researchers from developing or under developed countries. In our study, we designed a new method for determining blood pressure in animal model studies by using CONTEC 08A device with small cuff for rats. Ten male Wistar rats of 182-240 g body weight were randomly assigned to two groups (n=5/group). A group served as control (without treatment), the second group was administered dexamethasone (2mg/kg of body weight) supplemented with 4% table salt (NaCl) as drinking water to induce hypertension. Blood pressure was measured ten times in each rats of the two groups at baseline (day 0) and after 5 days. Reproducibility (Sw) was calculated in each group. CONTEC 08A yielded good reproducibility in both hypertensive (SBP, Sw=6 mm Hg, DBP, Sw=10 mm Hg) and non-hypertensive rats (SBP, Sw=3 mm Hg, DBP, Sw=6 mm Hg). Better reproducibility was obtained in non-hypertensive rats. Consistency in data obtained showed that noninvasive blood pressure monitoring using CONTEC 08A device with small cuff is effective, and recommendable for use in rat model study of hypertension.

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