Journal of Clinical and Molecular Endocrinology

Metabolic changes in patients with type 2 diabetes and secondary insulin resistance

11^th International Conference on Endocrinology and Diabetology
August 09-10, 2018 Madrid, Spain

Garoyan V and Temnenko N

RUDN University, Russia

Posters & Accepted Abstracts: J Clin Mol Endocrinol

DOI: 10.21767/2572-5432-C2-006

Abstract

Purpose: The purpose of this work is to study the features of laboratory indicators in patients with type 2 diabetes who received insulin therapy depending on the insulin dose. Methods & Materials: Seventy three patients of both sexes were examined and treated in the endocrinology department of the municipal clinical hospital. Patients age ranged- 45 to 70 years old. Depending on the dose of insulin (within physiological need or higher) patients were divided into 2 groups. Patients in the first group (45 people) were treated with insulin dose ≤40 U/day; the second group (28 people) received insulin >40 U/day. During the exam-ination of patients, special attention was paid to study the following parameters: the current age of the patient and the age at the beginning of the disease, duration of type 2 diabetes, body mass index (BMI). The determination of fasting and postprandial glycemia, glycated hemoglobin (HbA1c) were included in glycemic control. Laboratory parameters like choles-terol, high-density lipoproteins (HDL), low-density lipoproteins (LDL), very-low-density lip-oproteins (VLDL), triglycerides, atherogenic index, crude protein, level of creatinine and urea, transaminases; insulin level and C-peptide have been analyzed. Results: Parameters of the average age of patients in both groups had slight difference (61.2±3.9 and 62.3±4.5 years), at the beginning of the manifestation of type 2 diabetes, pa-tients from second group (48±4.4 years) were significantly younger than patients of the first group – 54.6±2.1 years. Patients in second group were more likely to have obese (BMI=34.8±3.2 kg/m2) than patients in first group (BMI=28.8±2.8 kg/m2), which partially explains the higher need for exogenous insulin. No significant differences were found be-tween groups according to the daily glycemic control criteria. Patients in group 1 had higher rates of pre-prandial glycemia than in group 2 – postprandial glycemia. Level of НbА1�? in patients of the first group is – 8.23±0.6%, in second group is – 9.92±0.4%. There were no significant differences in mean values of patients of different groups in the structure of lipid profile. Patients of the second group, in which tendency to enhanced atherogenic index has been observed. The values of cholesterol-HDL, VLDL and triglycerides were higher in pa-tients with a total daily dose of insulin ≤40 U/day. Remnant of insulin secretion remained unchanged in both groups. C-peptide level in group 1 was 1.41±0.13, was 0.93±0.21 ng/ml in second group (at reference values 0.78- 1.89 ng/ml). The correlation (Spearman Rank Order Correlations) of the HbA1c index with the C-peptide level was more significant (r=-0.39, p<0.01) than the correlation of this indicator with the dose of insulin (r=-0.17, p<0.05). Conclusion: The risk factors of secondary insulin resistance in patients with type 2 diabetes include: the duration of the disease more than 10 years, BMI over 34 kg/m2 and the age to the manifestation of diabetes below 50 years.

Biography

Garoyan Vera Ogannesovna a 6th year student of RUDN-university, Moscow, Russia. Papers published: “Clinical Gerontology” ISSN: 1607-2499 AORTIC VALVE STENOSIS IN PA-TIENTS OF ELDERLY AND SENILE AGE. Area of research interest: Endocrinology and Cardiology.

E-mail: vera.garoyan@ro.ru