Effect of ethyl acetate leaf fraction of Gongronema Latifolium on alloxan induced diabetes rats

Joint Event on 3rd World Congress on NATURAL PRODUCTS CHEMISTRY AND RESEARCH & 12th WORLD PHARMA CONGRESS
October 16-18, 2017 Budapest, Hungary

Effiong, Grace Sylvester and Ekpe Ini Patrick

University of Uyo, Nigeria The Catholic University of Nigeria, Nigeria

Posters & Accepted Abstracts: Am J Ethnomed

DOI: 10.21767/2348-9502-C1-003

Abstract

Diabetes mellitus is a metabolic disorder caused by insufficient or absent production of the hormone insulin by the pancreas. The effect of ethyl acetate fraction of Gongronema latifolium on body weight, blood glucose level and lipid profile was evaluated in alloxan-induced diabetic rats using standard methods. The result revealed that there is a significant increase in body weight of Groups 2(15.17%), Group 3(12.05%) and group 4(14.05%) after 14 days treatment when compared with untreated diabetic rats (-5.61%). The effect of treatments on blood glucose level of alloxan-induced diabetic rats shows a significant increase (P<0.05) of percentage change of blood glucose in group 2(43.05%), 3(23.50%) and 4(43.36%) when compared with group 1(8.87%) and also a significant increase (P<0.05) in groups 2 and 4 when compared to group3 on the 14th day of treatment. The results of the determined serum lipid profile indicates a significant decrease (P<0.05) in the levels of serum TC, TG, LDL-C and VLDL-C and a significant increase (P<0.05) in the level of serum HDL-C of group 2(TC=3.01 ± 0.12mg/dl, TG=2.31 ±0.14mg/dl, LDL-C=0.83 ± 0.28mg/dl, VLDL-C=0.46 ± 0.34mg/dl and HDL-C=1.72 ± 0.29mg/dl), Group 3(TC=4.56 ± 0.96mg/dl, TG=2.52 ± 0.24mg/dl, LDL-C, 1.13 ± 0.09mg/dl VLDL-C=0.95 ± 0.16mg/dl and HDL-C=1.27 ± 0.10mg/dl) and Group 4(TC=3.56 ± 0.64mg/dl, TG=2.36 ± 0.16, LDL-C=0.09 ± 0.14mg/dl, VLDL-C=0.67 ± 0.32mg/dl and HDL-C=1.47 ± 0.15mg/dl) when compared with the group 1(TC=9.92 ± 1.02mg/dl, TG=3.18 ± 0.26mg/dl, LDL-C=7.74 ± 1.86mg/dl, VLDL-C=1.11 ± 0.12mg/dl and HDL-C=1.08 ± 0.11mg/dl,). Consequently, treatment with the fractions and standard drug reverse the alloxan effect. This study thereby indicates that ethyl acetate leaf fraction of Gongronema latifolium may exert a hypoglycemic effect and could improve the lipid profile concentrations in diabetic rats.

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